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Beginner7 min readUpdated 9 October 2026

How to invest in healthcare

How drug makers, biotech, medical devices and insurers differ, and why a sector called defensive still carries real risks.

General education, not personal advice. Companies and funds are named as examples, not recommendations. Investments can fall as well as rise.

The short answer

Healthcare includes drug makers, biotechnology companies, medical device makers, health insurers and the suppliers of laboratory equipment. You can invest through individual companies, a healthcare fund, or your own portfolio. Demand is steady because people need treatment whatever the economy is doing, but drug patents expire, trials fail, and governments have a large say over prices.

  • Demand for healthcare holds up in recessions, which is why the sector is called defensive.
  • A drug's profits are protected by patents that run out, after which sales usually fall sharply.
  • Biotech is much riskier than large drug makers: a single trial result can decide a company's future.
  • Governments influence drug prices, so politics matters.
Part 1

Why it is called defensive

People do not stop taking medicine or needing operations in a recession, so healthcare companies' sales tend to be steadier than those of carmakers or retailers. Ageing populations in most wealthy countries add to long-term demand.

Steadier does not mean immune. Individual healthcare companies have suffered very large falls.

Part 2

The patent clock

A new drug is protected by patents for a limited time. While they last, the company can charge a high price. When they expire, cheaper copies arrive and sales of the original often drop sharply. This is known as a patent cliff.

A drug maker is therefore always racing to replace its best sellers. Checking how much of a company's sales come from one or two drugs, and when their patents end, tells you a lot.

Part 3

Biotech is a different animal

Large drug makers have dozens of products. A small biotech company may have one, still in clinical trials. If the trial succeeds the shares can multiply. If it fails they can lose most of their value in a day.

Most experimental drugs do not make it to market. Holding many biotech companies spreads that risk but does not remove it.

Part 4

Politics sets prices

In most countries the government is the main buyer of healthcare, directly or indirectly, and negotiates what it will pay. In the US, drug pricing and health insurance are recurring political issues.

A change in pricing rules can alter a company's profits without anything changing about its products.

Part 5

The parts of healthcare

  • Large drug makers

    Develop and sell medicines worldwide.

    For example: Eli Lilly, Novo Nordisk, AstraZeneca, Johnson & Johnson

  • Biotechnology

    Develop newer kinds of treatment. Ranges from large and profitable to tiny and unproven.

    For example: Amgen, Vertex Pharmaceuticals, Regeneron

  • Medical devices

    Make equipment used in hospitals and by patients.

    For example: Medtronic, Abbott Laboratories, Intuitive Surgical

  • Insurers and services

    Pay for and organise care, mainly in the US.

    For example: UnitedHealth, Elevance Health

  • Laboratory tools

    Supply the equipment drug makers and labs depend on.

    For example: Thermo Fisher Scientific, Danaher

Companies are listed to show what each category means. They are not recommendations, and the list is not complete.

Part 6

Three ways to invest

There is no single right route. Many people combine them, and plenty decide a broad global fund is all they need.

  1. 1

    Buy individual shares

    Pick one or more healthcare companies and buy their shares through a broker or investing app.

    Good for
    Simple to understand. You own exactly what you chose.
    Watch out for
    If you only hold a few companies, one bad result can do real damage. Picking winners is hard, even for professionals.
  2. 2

    Buy a ready-made fund

    A fund (often an ETF) holds dozens of companies in one purchase. Examples include the Health Care Select Sector SPDR Fund (XLV) and Vanguard Health Care ETF (VHT) in the US, and the Xtrackers MSCI World Health Care UCITS ETF (XDWH) in the UK and Europe.

    Good for
    Instant spread across many companies, with very little effort.
    Watch out for
    You get what the fund provider chose, including companies you may not want. Themed funds usually charge more than broad trackers, so check the yearly fee and the top ten holdings. Which funds you can buy depends on where you live.
  3. 3

    Build your own portfolio

    Choose your own mix of companies and how much of each, then buy them through your broker. This is what Arithmos helps with: describe the mix in a sentence and it builds and tests one for you to consider.

    Good for
    You decide exactly what is in and what is out, and you can see the reason for every company.
    Watch out for
    More to look after than a fund. Buying many separate shares can cost more in dealing fees, and a tested result is a simulation, not a promise.
Part 7

What $100 would have done

To make this concrete, here is a real portfolio from this area that anyone can open on Arithmos, and what $100 put into it would be worth. It is one example, shown as it is, whether it went up or down.

A real example
Longevity & Healthspan

If you’d put $100.00 into this portfolio of 12 companies…

Try your own amount and dates
Part 8

The risks

Read this before investing
  • Patent expiry. Sales of a best-selling drug can fall quickly once copies are allowed.
  • Trial failures. Promising treatments often fail in late-stage testing.
  • Price regulation. Government decisions can cut profits.
  • Legal action. Drug and device makers face large lawsuits over safety.
  • Dependence on a few products. Some very large companies rely heavily on one area, such as weight-loss drugs.
Part 9

Try it yourself

The quickest way to understand a portfolio is to look at one. Here is how to turn this guide into something you can inspect.

  1. 1

    Start from the idea

    The button below opens the builder with this guide's idea already typed in. Change any part of it: the number of companies, the countries, the limit per company.

  2. 2

    Read the reason for every company

    You get a list of companies, how much of each, and a plain-English reason for each pick. If one looks wrong to you, you can ask for it to be changed.

  3. 3

    Look at the bad years, not just the good ones

    The portfolio is replayed against real past prices. Check the biggest fall along the way, and ask yourself whether you could have sat through it.

  4. 4

    Decide for yourself

    If you want to act on it, you buy the shares yourself through your own broker. Arithmos never holds your money or places trades.

The idea

“Large healthcare companies worldwide: drug makers, medical device makers and health insurers. 25 companies, bigger companies get a bigger share, no company over 8%.”

Browsing portfolios other people have published is free. See pricing for what building your own includes. A tested result is a simulation using past prices. It is not a forecast and not a recommendation.

Part 10

Common questions

What is the difference between pharma and biotech?

The line is blurry. Pharma usually means large companies with many established medicines. Biotech usually means companies developing newer biological treatments, many of them smaller and riskier.

Are healthcare stocks safe in a recession?

Their sales tend to hold up better than most, but share prices can still fall, and individual companies face risks of their own such as patent expiries and failed trials.

What is a patent cliff?

The sharp drop in a drug's sales after its patents expire and cheaper versions go on sale.

This guide is general education and does not take your personal circumstances into account. It is not investment, tax or legal advice, and it is not a recommendation to buy or sell anything. Companies and funds are named as examples of a category. The value of investments can fall as well as rise and you may get back less than you put in. Past performance, real or simulated, is not a reliable guide to the future. Arithmos is a research tool, not a regulated broker or financial adviser. See our risk disclaimer.

A research tool, not investment advice. Past performance doesn't guarantee future results. Learn more