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Index
Longevity & Healthspan Index
official“An index of biotech, diagnostics, and consumer health companies researching biological aging reversal, senolytics, and longevity interventions — targeting the $610B anti-aging market.” — by Ling Holloway
built · 2026-04-30 22:12·rebalance · semiannual·next run · 2026-10-30
backtest · S&P 500 (SPX)·range
CAGR—
Annual vol—
Sharpe—
Sortino—
Max drawdown—
Best year—
Worst year—
risk-free raterf = 4.50%
vs S&P 500 (SPX) · 1M—
vs S&P 500 (SPX) · 1Y—
vs S&P 500 (SPX) · 2Y—
vs S&P 500 (SPX) · 3Y—
vs S&P 500 (SPX) · 5Y—
vs S&P 500 (SPX) · 10Y—
no backtest data
sharpe ratio
| ticker | weight | YTD | 1Y | 3Y | 5Y | 10Y |
|---|---|---|---|---|---|---|
| UNITY | 12.0% | — | — | — | — | — |
| EXAS | 10.0% | — | — | — | — | — |
| ILMN | 10.0% | — | — | — | — | — |
| VCNX | 9.0% | — | — | — | — | — |
| ALDX | 9.0% | — | — | — | — | — |
| BNTX | 9.0% | — | — | — | — | — |
| REGN | 9.0% | — | — | — | — | — |
| ABBV | 8.0% | — | — | — | — | — |
| NVO | 8.0% | — | — | — | — | — |
| AMGN | 7.0% | — | — | — | — | — |
| HIMS | 5.0% | — | — | — | — | — |
| AGEN | 4.0% | — | — | — | — | — |
| weighted | 100% | — | — | — | — | — |
attribution factsheet
holdings · 12
click a row to drill in ↗NameAllocationRationale
UNITYUnity BiotechnologyHealthcare12.00%Senolytic pioneer targeting age-related diseases; ocular program in Phase 2.EXASExact SciencesHealthcare10.00%Multi-cancer early detection (MCED) Cologuard platform extending healthy lifespan.ILMNIlluminaHealthcare10.00%Genome sequencing foundation for longevity research and personalized medicine.VCNXVaccinexHealthcare9.00%Neurodegenerative disease pipeline (Huntington's, Alzheimer's) targeting age-onset conditions.ALDXAldeyra TherapeuticsHealthcare9.00%Reactive aldehyde species (RASP) inhibitor targeting systemic inflammation — a root cause of aging.BNTXBioNTechHealthcare9.00%mRNA platform developing individualized cancer vaccines and aging-related immuno-therapies.REGNRegeneronHealthcare9.00%Dupixent and pipeline antibodies tackling age-related inflammatory diseases.ABBVAbbVieHealthcare8.00%Skyrizi/Rinvoq immunology franchise plus aesthetics; longevity wellness overlap.NVONovo NordiskHealthcare8.00%GLP-1 drugs (Ozempic/Wegovy) linked to dementia reduction and cardiovascular longevity.AMGNAmgenHealthcare7.00%AMG 133 weight-loss bispecific + bone-density agents for age-related musculoskeletal decline.HIMSHims & Hers HealthHealthcare5.00%Consumer telehealth scaling access to longevity interventions (GLP-1, hormone therapy).AGENAgenusHealthcare4.00%Checkpoint inhibitor antibody pipeline targeting age-related immune decline and cancer.
weighting · equal
rebalance · semiannual
